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However, as with any type of medical treatment, every individual is different and there are several factors that will influence how long you might stay on Semaglutide, including: Your weight-loss response to the medication Your individual goals Whether you experience any side effects Your commitment to diet and exercise changes Effects of Semaglutide long-term Given that semaglutide is designed to be used long-term, the effects of long-term use are generally all positive ones especially when combined with healthy lifestyle choices