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More severe GI side effects were seen in oral administration, and injections were associated with irritation at sites of administration [1]

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As clinical pharmacology data of oral semaglutide were characterised by high within-subject variability, potential changes to the disposition model obtained by including oral data were judged to be less credible, as the changes could be the result of changed estimation procedures and difficulties with the estimation

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The result is a patchwork system where access to these medications remains inconsistent, despite the administrations efforts to streamline availability