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Activated microglia and astrocytes release proinflammatory cytokines including tumor necrosis factor-alpha (TNF- ), interleukin-6 (IL-6), and interleukin-1 (IL-1), creating a hostile neuroimmune milieu (Isik et al., 2023

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Clinical data and animal experiments suggest that BBB dysfunction such as impairments to TJs or AJs as well as changes in EC function, plays a critical role in the pathogenesis of seizures and epilepsy [69, 70]