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Hum Pathol 35:10007, PMID: 15297967 Pai HV, Starke DW, Lesnefsky EJ, Hoppel CL, Mieyal JJ (2007) What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria

None of the Marketing Authorisation Holders in the UK use any clinical evidence for optimal dosage of 3 monthly treatment and base the information written in their Patient Information Leaflet upon BNF Guidelines and the Martindale Drug Reference book

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Mechanistically, MitoCur-1 significantly inhibited USP14 and inactivated the GPX4 enzyme while exacerbating GSH depletion and reducing SLC7A11 expression levels