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Description

The conversion of ribonucleotides to deoxyribonucleotides (through the action of ribonucleotide reductase) requires NADPH as the electron source, therefore, any rapidly proliferating cell needs large quantities of NADPH

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10.1016/s2213-8587(20)30074-7 71 YamadaY.KatagiriH.HamamotoY.DeenadayalanS.NavarriaA.NishijimaK.et al (2020)

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The limited blood supply compounds this problem by restricting the delivery of fibroblasts and growth factors needed for repair

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