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En boca se considera que se presentaran los tres primeros y probablemnte el melanoma acral lentiginoso sea el ms frecuente y se caracteriza por hiperplasia del epitelio, con marcada actividad melanoctica en estrato basal con presencia tambin en estratos espinosos y ms superficiales de melanocitos atpicos, los cuales tambin han infiltrado hacia el corion

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doi: 10.1038/nrm3667 72 YildizAZhaoY