That fragment acts on a target the same Washington State group helped pin down: the so-called AT4 receptor, which was identified as IRAP, insulin-regulated aminopeptidase, an enzyme rather than a classical receptor (Albiston et al., J Biol Chem 2001)
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Moreover, the inclusion complex formulation displays an increased shelf life at room temperature [114,115]
REDEFINE Trial Headlines Trial REDEFINE 1 Phase 3 Duration 68 weeks Population (N) 3,417 adults with obesity or overweight + 1 comorbidity, without T2D Key Result 20.4% mean weight change vs 3.0% placebo (treatment-policy)
