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Some of the most interesting targets in potential weight-loss drugs are analogs of hormones that act in hunger- and satiety-related metabolic pathways, says Indiana University Bloomington chemist Richard DiMarchi, a former Lilly researcher who sold his diabetes start-ups to Novo Nordisk

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Early observational data helps patients anticipate realistic milestones and avoid disappointment or premature discontinuation based on initial weeks alone

What matters is obtaining prompt medical evaluation and ensuring that symptoms, diagnoses, and timelines are well documented

Physical activity levels often decline as well, partly due to symptoms like fatigue and joint discomfort