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A small cooler or insulated bag becomes essential if you travel with reconstituted retatrutide
In L-cells of the lower intestine and colon the proprotein convertase subtilisin/kexin type 1 (or PCSK1/PC1) cleaves after single or double basic amino acids to liberate glicentin (amino acids 21-89 in proglucagon), oxyntomodulin (amino acids 53-89 in proglucagon), GLP-1 (amino acids 92-128 in proglucagon), and GLP-2 (amino acids 146-178 in proglucagon) (see UniProt P01275)
Notably, GLP-1 receptor agonists also slow biliary motility, which can contribute to the development of bile ductblocking sludge and stones, resulting in acute pancreatitis
Conclusion GI AEs are the most common effects of GLP-1 RAs and dual GIP/GLP-1 RAs, often manifesting during initiation and dose escalation
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