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Migraine headache is a common disease that affects millions of individuals worldwide
Specifically, NICE suggests considering a DPP-4 inhibitor as a second agent when: The patient has a high risk of hypoglycaemia (making sulfonylureas less suitable) Weight management is a concern and a sulfonylurea's weight-gaining effects are undesirable An SGLT-2 inhibitor is contraindicated or not tolerated NICE NG28 recommends that in patients with established atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease, an SGLT-2 inhibitor should generally be prioritised often alongside or instead of metformin due to its organ-protective benefits
Furthermore, berberines role in gluconeogenesis and lipid metabolism extends to improving overall metabolic health, which is crucial for patients suffering from NAFLD, a condition closely linked to metabolic syndrome
