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Multivariate analysis revealed that the hepatic GLP-1R level was independently associated with hepatic steatosis (Table 1)

8a) but still retained substantial GGT activity (Extended Data Fig

Check serum creatinine and eGFR at baseline and within 4 weeks of any dose change in patients with CKD stage 3b or higher

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Based on the crucial role that ROS play in the pathology and pharmacological treatment of a wide range of diseases, therapeutic strategies targeting the regulation of ROS homeostasis hold significant clinical value for revealing the molecular mechanisms of diseases, promoting drug development, and advancing personalized treatment