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Interestingly, among those fed a Western-diet, those who had highest amounts of P

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This response activates the pathways involved in producing cytokines, such as interleukin-2 (IL-2) and interferon-gamma (IFN-), to coordinate an immune response to prevent the growth and dissemination of M

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47 , 48 , 49 , 50 , 51 An early study of MC1R variants in humans by Valverde et al reported an association of specific variants with red hair colour, fair skin and impaired tanning response to UV radiation, with MC1R variants identified in 82% of patients with red hair