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Retrieved from Zhang, J., Wei, J., Lai, W., et al

Collectively, all GLP-1 receptor agonists, including native GLP-1, peptides, and small molecule GLP-1 receptor agonists, stabilize the binding pocket of the GLP-1 receptor in a similar fashion, which induces the TM helices 6 kink, a distinctive feature of the active state of the class B1 GPCR

As a result, misfolded and polyubiquitinated proteins accumulate within the ER, activating the UPR and promoting apoptosis