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In 2025, before the Wegovy pill was approved, the Wegovy injection was approved for treating the liver disease metabolic-associated steatotic hepatitis (MASH)

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Dosing typically starts at 1mg weekly and gradually increases to 4mg or higher, with most users finding their sweet spot between 4mg and 8mg when combined with anabolic compounds

Consistently, the mRNA and protein levels of hepatic CYP8B1 were elevated, while the percentage of 12-OH BAs was increased and the proportion of non-12-OH BAs was reduced in the gallbladder bile, ileum, liver, serum, and urine in MMI mice compared to untreated control mice (CT mice) (Supplementary Fig