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The large cardiovascular outcomes trials of GLP-1 receptor agonists (LEADER, SUSTAIN-6 and REWIND) have confirmed that this class of medication can lower major adverse cardiovascular events by 12-14% in high-risk individuals, and the link between percent weight loss and cardiovascular risk reduction has led to the expectation that higher percent weight loss will yield greater incremental cardiovascular benefits if this class of drug can be used in combination with amylin receptor agonists

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An increase in melanin in the skin can cause age spots, melasma, and sun spots to develop on different areas of skin on the face, hands, and body