Assessments Serial assessments of randomly assigned participants are conducted throughout all of the trials and include height, body weight, waist circumference, glucose metabolism (fasting plasma glucose, HbA 1c , fasting serum insulin), lipids (total cholesterol, free fatty acids, highdensity lipoprotein cholesterol, lowdensity lipoprotein cholesterol, triglycerides, verylowdensity lipoprotein cholesterol), biomarkers (highsensitivity Creactive protein, except in the sustained WM trial [STEP 4]), and vital signs (diastolic and systolic blood pressure [millimeters of mercury])
doi: 10.1210/jc.2005-1536
5.2 Reduction of oxidative stress and endoplasmic reticulum stress Chronic hyperglycemia and endothelial activation drive excessive generation of ROS, promoting mitochondrial dysfunction, endothelial apoptosis, and reduced NO bioavailability
The authors speculate that GLP-1 drugs might influence the risk of so many conditions for two reasons: first because they act on many parts of the body, and second because they treat obesity, which contributes to several health issues
Unfortunately, some of these medications have been linked to severe side effects, including heart problems, gastrointestinal issues, and even cancer
