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The quality of log-linear regression and, consequently, the reliability of the extrapolated pharmacokinetic parameters (namely z , t , AUC 0 , AUC extra , V z , CL r and CL t ) was demonstrated by a determination coefficient, R 2 0.8

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In the studies reviewed, two widely used hepatocellular models were employed to assess hepatotoxicity of environmental contaminants: the hepatocellular carcinoma line HepG2 and the bipotent progenitor line HepaRG