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La administracin de la liraglutida tiene efectos agudos similares a GLP-1 en el censo de la glucosa y la secrecin de insulina a travs del cierre de los canales de K dependientes de ATP, cambio en el potencial de la membrana y sensibilizacin de la clula beta pancretica a la glucosa28, liberacin de los depsitos internos de calcio inico29, y disminucin de los canales de K dependientes de voltaje30