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These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005

Precautions apply for patients with known allergies, asthma history, pregnancy, lactation, or significant underlying illness, based on local medical guidance

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Targeted probiotic strains and supportive nutrients help address these drivers rather than treating digestion in isolation