In a 52-week phase II trial involving patients with MASH and advanced fibrosis, tirzepatide demonstrated dose-dependent benefits in resolving MASH, with the highest dose achieving a resolution rate of 62%
He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance
Bile acids can also stimulate GLP-1.[ref] Importantly, modern exposure to glyphosate and antibiotics may be reducing our natural, constant GLP-1 levels: Animal studies show that GLP-1 levels are reduced due to gut microbiome changes from glyphosate.[ref] Studies using germ-free mice show that GLP-1 secretion after a meal is abolished without the gut microbiome.[ref] How GLP-1 Controls Appetite and Prevents Binge Eating GLP-1 regulates appetite through several distinct mechanisms that affect the brain and the gut
Slowing down this process makes us feel fuller for longer, leading to lower calorie intake
This creates an outlet obstruction
