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Collagenase injections (Xiaflex) represent the most effective FDA-approved non-surgical treatment, with clinical studies showing 34% improvement in penile curvature

Research shows GHK-Cu reduces iron release from ferritin by 87%, preventing iron-catalyzed lipid peroxidationa chain reaction producing free radicals that damage DNA, proteins, and cell membranes

These features are similar to those described by Ghafarizadeh et al

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However, these monitoring principles are consistent with general geriatric diabetes care and do not yet justify phenotype-specific targets unique to SAGE-DM