Contributor Information Collaborators: PIONEER 8 Investigators, Bernard Zinman, Sameh Fikry, Harpreet Bajaj, Daniel Landry, David Caplan, Vincent Woo, Stewart Harris, Jean-Francois Thuan, Pierre Serusclat, Bertrand Cariou, Pierre Gourdy, Gerard Fradet, Arnaud Monier, Sophie Borot, Pascal Monguillon, Didier Gouet, John Doupis, Nikolaos Tentolouris, Vasileios Tsimichodimos, Andreas Melidonis, Eleni Bekiari, Alexandra Bargiota, Sanjay Agarwal, Banshi Saboo, Sanjay Chatterjee, Viswanathan Mohan, Shehla Shaikh, Yashdeep Gupta, Arpandev Bhattacharyya, Neeraj Manikath, Sunil Jain, Takashi Sasaki, Takeshi Osonoi, Shuichi Fukuda, Seiki Wada, Arihiro Kiyosue, Yumiko Ide, Yukiko Onishi, Kiyokazu Matoba, Kuninobu Takai, Akira Yamauchi, Satoshi Inoue, Shizuka Kaneko, Hiroki Ikeda, Yasuharu Ohta, Akitaka Hisatomi, Takafumi Senokuchi, Hideaki Jinnouchi, Shuji Nakamura, Jos Roberto Lazcano Soto, Ignacio Rodriguez Briones, Pawel Bogdanski, Ewa Szyprowska, Anna Modzelewska, Iwona Wozniak, Svetlana Zyangirova, Marina Sergeeva-Kondrachenko, Thomas Davis, Stephen Thomson, Juan Frias, Winston Gandy, Ildiko Lingvay, Kevin Pounds, Cynthia Bowman-Stroud, Michael Dempsey, David Huffman, Azazuddin Ahmed, Neil Fraser, Ramon Ortiz-Carrasquillo, D
It's important to distinguish between temporary adjustment side effects (common in weeks 14 at each dose step) and dose intolerance
Choose one repeatable option you can tolerate most days (eggs, Greek yoghurt, tuna/salmon, tofu, lean chicken, legumes)
A meta-analysis incorporating data from ten tirzepatide studies and involving over 6,800 participants found that tirzepatide at 15mg/weekly resulted in a 10% discontinuation rate due to adverse effects
Cachexia is a more advanced form of wasting that happens in people with serious chronic illnesses like cancer, heart failure, kidney failure, COPD, or HIV
