Your clinician will confirm your candidacy, review your medications, and establish a follow-up schedule tailored to your specific situation
In the early 1990s, it was discovered that the activity of the 20S proteasome is not restricted to complete degradation of its protein substrates, but that the complex can cleave at specific sites to generate functional cleavage products (Fan and Maniatis, 1991)
If SAH accumulates, homocysteine is poorly managed or sulfur-amino-acid substrate is inadequate, the liver may have less flexibility to maintain methylation while also supplying cysteine for glutathione and taurine
This is the starting line
Prevention includes slow dose escalation, dietary adjustments like eating small, bland meals, avoiding fatty or spicy foods, staying hydrated, and consulting your healthcare provider if symptoms become bothersome