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Oxidative stress happens when free radicals outnumber the antioxidants available to neutralize them, which can lead to cellular damage over time

In summary, plant GSTs may participate in the establishment of resistance to virus infections, either in the presence or absence of oxidative stress (HR-type necrosis) but could also contribute to the limitation of oxidative stress during virus susceptibility, i.e., in systemic infections

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Aging, poor diet, chronic illness, stress, sleep deprivation, and exposure to toxins can all contribute to low glutathione over time

Neuroscience 325 , 6373 (2016)