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Iron is needed for proper development of oligodendrocytes (the brain cells that produce myelin) (19), and the mineral is also a required cofactor for several enzymes that synthesize neurotransmitters (68)

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Interestingly, the phosphodiesterase inhibitor Cilostazol (used in peripheral vascular disease treatment) is able to improve cognitive function in mice by increasing the hippocampal production of IGF-I through stimulation of sensory neurons[350]