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Por accin de la enzima trimetil lisina dioxigenasa (TML-DO, EC 1.14.11.8) se hidroxila la posicin 3 de la TML para formar la 3-hidroxi- N 6 , N 6 -trimetil lisina ( HTML ) en presencia de oxgeno diatmico como agente oxidante, -cetoglutarato como aceptor de electrones, adems de hierro (II) y cido ascrbico como cofactores

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