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In mice plasma TMAO has been shown to be higher in female and TMA lower compared to males as Flavin-Containing Monooxygenase 3 (the main TMAO producing enzyme) expression is drastically downregulated by testosterone (and mildly upregulated by estrogen

Vitamin B12 is an essential water-soluble based vitamin that is stored in the liver

Sophisticated sponsors already apply similar reasoning implicitly

Bani Saeid A, Patel VK, Mehndiratta S et al (2023) Dissecting the in vitro fate of plant-derived bioactive encapsulated nanoparticles in lung diseases