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Our findings suggest that primary care providers could consider prescribing phentermine to patients who have discontinued GLP-1 medications, especially if they lost less than 20 pounds while on the GLP-1 medication, Kersten Bartelt, RN, a clinician at Epic Research, told Healio

In clinical trials, participants taking the highest dose of tirzepatide lost an average of 22.5% of their body weight over 72 weeks

Walker LS, Sansom DM

Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): A double-blind, randomized, placebo-controlled, parallel-group, multinational, multicenter phase 3a trial

This is why supplementation is necessary