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10.1200/JCO.23.02745 40 Gratacos-GinesJ.ArinoS.Sancho-BruP.BatallerR.PoseE
V., Treberg J
Hypertrophic adipocytes can promote the infiltration of macrophages into adipose tissue, thereby creating a local microenvironment characterized by a pro-inflammatory state, manifested by increased production of various cytokines, including tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and chemokines
R 9 is H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 2 -C 7 heterocycloalkyl, C 6 -C 10 aryl, C 3 -C 9 heteroaryl, C 1 -C 6 alkylC 6 -C m aryl, or C 1 -C 6 alkylC 3 -C 9 heteroaryl
However, because retatrutide remains investigational, its benefits must be interpreted alongside its evolving safety profile, dose-related side effects, and the need for ongoing clinical monitoring
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