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Even mild suboptimal potassium levels, common in people who are not eating well or who are losing potassium through GI fluid losses, can change the electrical behavior of the heart enough to generate palpitations

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Directly, semaglutide has not been shown to harm kidneys and cardiovascular outcome data suggests potential kidney-protective effects in patients with type 2 diabetes.[11] Indirectly, GI side effects that cause dehydration can strain renal function in patients with pre-existing impairment