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Antiviral ISG effectors were among the most highly induced and abundant proteins in the infected host cells, such as MX1, cGAS, OAS1-3, IFIT1-3, ISG15, FKBP4, PIGR, and UBE2L3/5, which function in sensing and degradation of viral RNA, inhibition of ribonucleocapsid uncoating, translation and promote the innate immune response (Table 1, Supplementary Table 3, and Figures 5A, 7A,B)

Semaglutide 2.0 mg vs semaglutide 1.0 mg in subjects with type 2 diabetes (SUSTAIN FORTE): a randomised, double-blind, phase 3b trial