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What is changing is how broadly they are being studied and how often they are discussed outside traditional regulatory and clinical frameworks (Rossino et al., 2023)

Preclinical studies using germ-free or antibiotic-treated animals have demonstrated impaired muscle mass, mitochondrial function, and endurance capacity, which are restored upon colonization with healthy microbiota or supplementation with specific probiotics such as Lactobacillus plantarum TWK10 and Bifidobacterium longum OLP- 01 [72,73,74,75]

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For the natural components with therapeutic effects, it is believed that future studies need to study deeply, and to improve the delivery route by combining nanotechnology and other methods to exert the best drug effect