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As a result, signalingmetabolism feedback loops emerge, creating robust systems that preserve CSC traits

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In this context, arginase 1 expression is important for polyamine and proline synthesis by tumor cells and cancer-associated fibroblasts (CAFs), providing them (CAFs) with the carbon backbone for collagen and ECM synthesis that fosters ovarian tumor growth and metastasis in a mouse model [97]

Glutathione is widely used clinically in the treatment or adjunctive therapy of diseases such as hepatitis, cataracts, and heavy metal poisoning