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Cell 168(5):758774 Frias JP, Bonora E, Nevarez Ruiz L et al (2021) Efficacy and safety of dulaglutide 3.0 mg and 4.5 mg versus dulaglutide 1.5 mg in metformin-treated patients with type 2 diabetes in a randomized controlled trial (AWARD-11)

Any immune or inflammatory settings in which the amount or activity of any of these proteins is lowered or does not increase appropriately (as we modeled with erastin) could dramatically perturb homeostatic balance and enhance T2 inflammatory factor expression and oxidatively driven cell death