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As such, and in response to these comments, we clarify that hospitals should report data from both prior to and after a contract negotiation date to capture a full 12-month period regardless of when the contract negotiation takes place

Alcohol is metabolized by the liver, which is the primary site of damage, and its abuse is the primary cause of several diseases, such as fatty liver, alcohol-associated hepatitis, and cirrhosis

Small-molecule inhibitors of cGAS enzymatic activity (e.g., RU.521, G140, PF-06928215) or STING signaling (e.g., H-151, C-176) have shown promise in preclinical neuroinflammation and neurodegeneration models by suppressing excessive type I interferon and cytokine production [12, 196]

S., Lee, J