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10.2174/1381612826666201118094502 176 SharmaS.BhatiaV

A recent study found that the ability of metformin to promote GLP-1 secretion was impaired in mice with a gut-specific knockout of the PEN2 gene (Ma et al., 2022)

(7) Use In Specific Populations Pregnancy: May cause fetal harm

2.3 Dose Modifications for Drug Interactions Dosage adjustments are recommended in patients taking concomitant strong CYP3A4 or CYP2C8 inhibitors or strong CYP3A4 or CYP2C8 inducers [see Drug Interactions (7.1), Clinical Pharmacology (12.3)]