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s protein, the addition of MK-0677 to rat primary cultured pituitary cells increased intracellular Ca 2+ levels, suggesting the existence of a second G protein-coupled receptor (GPCR) that couples with the G q protein, thereby promoting GH secretion through a pathway distinct from that of GHRH-R ( Xenopus oocytes injected with polyadenylated [poly(A) + ] RNA derived from the swine pituitary ( in situ hybridization revealed that it is expressed in the pituitary gland, as well as in the hypothalamus and hippocampus ( Table 1 The history of the discovery of GHS and ghrelin
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Secreted glucagon is recognized by the glucagon receptor (a G protein-coupled receptor) on the hepatocyte, subsequently adenyl cyclase-mediated productions of the second messenger cAMP was stimulated
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