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To infiltrate the islet, T cells must trigger the cathepsin-mediated loss of peri-islet ECM to bypass the peri-islet membrane ( Figure 2 )

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The horrible situation of a young woman, who was left untreated for several years, because her doctor considered a serum B12 concentration above 130 pmol/l as sufficient, has led me to question the following: why is solid medical information on how and when to treat people with B12 deficiency so poorly known