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Initial studies on fat-but-fit were observational, but now prospective randomized controlled trials have confirmed that physical fitness trumps the supposed downsides of being overweight or obese and that it is better to be fit and overweight / obese than unfit, whether normal weight or otherwise

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Influence of recent intake: Recent B12-rich meals or injections can temporarily raise serum levels, potentially masking a deficiency

To put these figures in concrete terms: The 56 percentage point difference between retatrutide and tirzepatide may appear modest in relative terms, but at population scale it represents a clinically meaningful separation

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