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28 Electrical stimulation has also been shown to enhance mitochondrial biogenesis by activating peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key regulator of energy metabolism and mitochondrial function in regenerating tissues

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The GST-tagged Sh HTL7 was purified similarly using 50 mM Tris-HCl, pH 8.0, 200 mM NaCl, 1 mM DTT, with 0.1% (v/v) Tween-20 added for lysis, and loaded on Glutathione Sepharose 4B (Cytiva) resin

However, the minor allele at rs12720356 was found to have no effect on STAT phosphorylation or cytokine production, while the protective allele at rs3456443 did reduce phosphorylation and cytokine stimulation in peripheral blood immune cells (121)