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FIGURE 4 Changes in Aging and Disease States As elegantly documented by Dean Jones over many years ( Regulation of Hepatic Redox State Reactive oxygen species also increases in response to excess fuels, as described in section Redox Components in perfused liver: lactate plus pyruvate and FFA stimulate ROS production

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In other words, sustained weight loss may help reduce breast cancer risk in some populations

Mitochondria functional assays demonstrated that HC modulated OCR in manner comparable to the mitochondrial uncoupler FCCP, supporting the hypothesis that HC acts as a functional mitochondrial uncoupler, similarly to other anthraquinones (Simeone, 2025)

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