In WT and obese animals, AOD9604 reduces fat mass, increases 3-AR expression, enhances lipolysis, and stimulates energy expenditure and fat oxidation
Visceral fat is particularly responsive to exercise, even before you see changes on the scale
This helps prevent the buildup of harmful substances and promotes overall health
Androgen depletion causes AR gene and/or enhancer amplification, which renders AR more sensitive to lower levels of ligands, and induces somatic mutations that broaden ARs ligand-binding spectrum or turn antagonists into agonists [4, 26, 27]
Unfortunately, it is extremely difficult to measure the different forms, and most studies cannot differentiate the concentration of specific CCK forms 166,167,168,169