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In a study by Guan et al., PD-L1 was suppressed with ultrasensitive pH-triggered charge/size dual-rebound NPs loaded with plasmid DNA expressing the small hairpin RNA of PD-L1 in the melanoma mouse tumor model [249]

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Moreover, APEX2-mediated Btn-An labeling showed high spatial specificity in other subcellular compartments, such as nucleoli and nucleoplasm

Di Mauro S, Filippello A, Scamporrino A, et al