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The endogenous ligand GIP results in full agonism of the mouse GIPR, and the AMG 133 murine surrogate fully antagonized native GIP (IC 50 = 4.1 nM) (Extended Data Fig

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In addition, Ab#2_DSB#1 displayed equivalent terminal half-life in mice based on Fc detection and GLP-1R activity (Supplementary Table 4) with no significant loss of peptide activity for at least 7 days (Fig

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