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Clinical data showed that participants who were placed directly on 8mg without gradual titration experienced nearly double the rate of GI symptoms compared to those who followed the stepwise approach

Time-restricted eating may also improve insulin sensitivity and restore incretin responsiveness over time

Clinical research also shows that some neuroimaging features observed in people with obesity resemble those seen in people with addiction, says Lorenzo Leggio, MD, PhD, clinical director of the National Institute on Drug Abuse and corresponding author of the JES paper

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