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In humans, the CYP450 enzyme that predominately catalyses the formation of NAPQI is CYP2E1, although in vitro CYP3A4, CYP2D6 and CYP1A2 have also been implicated in the formation of the toxic metabolite [18,19,20]

Based on observational data, a 2011 report identified an increased risk for pancreatitis and pancreatic cancer in patients on incretin therapy 4 , which led to a Food and Drug Administration (FDA) warning on the pancreatic safety of GLP-1 agonists 5

Glutathione, also known as GSH, is an internal antioxidant our bodies produce that is found in every cell of the body

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