would glp 1 patches work Do GLP-1 for Weight Loss? What You're Really Getting GLP-1 Patches vs. GLP-1 Injections:

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To Raufman's surprise, in 1981 he discovered that when he put one of the peptides onto guinea pig pancreata, it caused a sharp rise in amylase, an enzyme made in the pancreas and salivary glands in the mouth to help the body break down carbohydrates (Raufman, Tensen, Sutliff

That discrepancy is the core of the concern

GIP (glucose-dependent insulinotropic polypeptide) is a hormone that may complement the effects of GLP-1 receptor agonists

Also, a meta-analysis on antidepressant effects of GLP-1 RA including 2071 participants showed reduced depression scores with GLP-1 treatment compared with controls [17]