at the same time, since the intracerebral hematoma releases hemoglobin (Hb)-based neurotoxin (Wang 2010), the neural damages secondary to perihematomal edema (PHE) that is caused by BBB disruption also occur in the brain parenchyma, becoming an important cause of morbidity and mortality in patients ( The release of Hb is due to the accumulation and dissolution of iron-rich erythrocytes in the brain parenchyma, which consequently leads to iron toxicity and induces the production of ROS (Wu et al., 2011), interfering with normal function of cells and resulting in neuronal death (Zecca et al., 2004)
Full texts were retrieved for studies meeting inclusion criteria
Murata K, Tani K, Kato J, Chibata I
JSB, JER, MK, and RAG contributed to the design of the experiments and analysis of the data
In some cases of IDH2 mutations another Arg residues is mutated to Glu (R140Q)