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"Tesamorelin for the treatment of HIV-associated lipodystrophy." Ther Clin Risk Manag

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Intranasal administration, though less studied with Dihexa specifically, would theoretically provide the most direct CNS delivery with minimal systemic exposurepotentially requiring even less frequent dosing to maintain effective brain tissue concentrations

Figure 1 A Cascade Hypothesis For long, A has been seen as the main causative agent in AD pathology that is followed by neurofibrillary tangles, vascular damage and neuronal loss as direct consequences of A deposition (Murphy and LeVine, 2010)