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Losing weight is not something your body wants you to do, its more or less an evolutionary fact that it is very much in support of you retaining excess calories to use as energy later when you are getting chased by a tiger or something

Brain cannabinoid CB(2) receptors modulate cocaine's actions in mice

The biological plausibility was strongGLP-1 RAs reduce inflammation, improve mitochondrial function, and may modulate pathways involved in neuronal survival